PD-1 (NAT105); 0.1ml; concentr

Code: 315M-94 D2-231

General description

Programmed death-1 (PD-1) is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PD-1 is a marker of angioimmunoblastic lymphoma and suggests...


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€248.50 EACH
€305.66 inc. VAT

General description

Programmed death-1 (PD-1) is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PD-1 is expressed by few B-cells, so anti-PD-1 may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma. In addition, PD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells. PD-1 expression in angioimmunoblastic lymphoma lends further support to this model of T-cell oncogenesis, in which specific subtypes of T-cells may undergo neoplastic transformation and result in specific distinct histologic, immunophenotypic, and clinical subtypes of T-cell neoplasia.

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Linkage

PD-1 Positive Control Slides, Product No. 315S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

For Technical Service please contact: 800-665-7284 or email: [email protected]

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Quality

IVDIVDIVDRUO

antibody formculture supernatant
antibody product typeprimary antibodies
biological sourcemouse
cloneNAT105, monoclonal
conjugateunconjugated
controltonsil
descriptionFor In Vitro Diagnostic Use in Select Regions (See Chart)
formbuffered aqueous solution
Gene Informationhuman ... PDCD1(5133)
isotypeIgG1
manufacturer/tradenameCell Marque
packagingvial of 1.0 mL concentrate (315M-96), vial of 0.5 mL concentrate (315M-95), bottle of 7.0 mL predilute (315M-98), bottle of 1.0 mL predilute (315M-97), vial of 0.1 mL concentrate (315M-94)
Quality Level100, 500
shipped inwet ice
species reactivityhuman
storage temp.2-8°C
technique(s)immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
visualizationcytoplasmic
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